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Centre de recherche

BOTTIN

Regenerating Intervertebral Discs: Harnessing the Use of Innate Bioactive Compounds

Dr Rahul Gawri, MD, PhD.

23/05/2017 @ 13:00 - LOEX R-138, Hôpital de l'Enfant-Jésus

Conférence

Organisée par : Julie Fradette

Intervertebral Disc (IVD) is a fibrocartilaginous tissue intercalating between adjacent vertebral bodies imparting flexibility to the human spine. In humans, degeneration of lumbar IVDs causes low back pain (LBP) with a huge economic burden worth 90 billion dollars in North America alone. At least 70% of individuals experience one episode of LBP in their lifetimes. IVD is the largest avascular and most hypocellular organ in the body, which makes tissue engineering applications for regenerating IVD a big challenge. Various strategies have been employed to attempt the regeneration of IVDs, such as use of extrinsic growth factors, stem cell injections, implantation of allogenic discs, decellularized discs seeded with IVD cells but none of these therapies have yielded expected results. Recently, the focus has shifted on identifying and testing bioactive compounds innate to IVDs and harnessing their potential to regenerate IVD, either by their administration alone or priming IVD cells with these compounds followed by implantation to attain desired outcomes with minimal side effects. Since these compounds are innate to IVD, local administration will have minimal systemic side effects.

This talk outlines two such bioactive compounds, Link-N peptide and Inorganic Polyphosphates and their evaluation and development for tissue engineering applications for regenerating IVDs.


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