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Research Center

Thursday 30 Mar

Geneviève Asselin et Martin Bussière, UETMIS, CHU de Québec - Université Laval


Les bains de chlorhexidine aux soins intensifs : évaluation de l'efficacité et de l'innocuité

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Three graduate student positions

Research project

Position: Three graduate student positions.

Description: Steroid hormones regulate essential physiological processes and inadequate levels are associated with various pathological conditions including hormone-dependent cancers, PCOS, and autoimmune and inflammatory diseases. Life-threatening conditions such as atherosclerosis, metabolic syndrome and diabetes have also been linked to testosterone deficiency. Steroid hormone synthesis in Leydig cells is finely regulated to avoid conditions of hormone insufficiency or excess. We have identified two pathways that are instrumental for steroidogenesis involving the CAMKI and AMPK kinases. We have also identified several novel transcription factors that regulate key genes required for steroid hormone synthesis and Leydig cell function.

Project 1. Role of the MEF2 transcription factor in testis differentiation and Leydig cell function.
Project 2. Characterization of the role of AMPK and identification of its targets in the fine regulation of steroidogenesis.
Project 3. Characterization of the role of CAMKI and identification of its targets in the fine regulation of steroidogenesis.

Beginning: Now until Summer 2017

Duration: Studentships are available for a period of 4 years (Ph.D.).

Job description

The projects involve molecular and cellular biology approaches (cell lines and primary Leydig cells, immunohistochemistry, siRNA, promoter analysis, DNA-protein and protein-protein interaction, intracellular signalling), gene editing (CRISPR/Cas9), animal models (transgenic mouse, cre-lox KO), and proteomic (TAP-LC-MS/MS) and genomic (ChIP-Seq, microarray/RNA-Seq) approaches.

Skills needed

Hold a BSc degree in biochemistry, microbiology, biology, biotechnology, or any related discipline. A preference is given to students enrolling in a PhD program. International students are welcome to apply at the PhD level only. Experience in molecular and cell biology and in proteomic techniques is an asset. Demonstrate strong motivation for basic biomedical research and good communication skills (English, French). Send your CV, transcripts, along with contact info for 2 references by email to Only the selected candidates will be contacted.
Offer number
Publishing date
18/08/2016 09:01
30/04/2017 17:00
Type of job
Étudiant doctorat
Main researcher
Jacques J. Tremblay
Reproduction, mother and youth health
48 months
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