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Research Center



Research project

The selected applicant will join the graduate program in molecular and cellular biology at the Faculty of Medicine of University Laval. He/She will participate to the preparation of the manuscript for publication and will be asked to present his/her results in national and international meetings. The candidate will work in a bilingual environment while the University and the city are French speaking. Salaries are based on Canadian Institutes for Health Research (CIHR) guidelines).

Job description

Maintenance of genomic integrity throughout different chromatin structure

The Research center: Our laboratory is located at the CHU de Québec Research Center – Hotel-Dieu, which is based in the heart of the fortified city of Québec. Furthermore, our team is affiliated with the Cancer Research Center of Laval University, which gathered a group of 20 multidisciplinary teams striving to understand the molecular mechanisms that drive oncogenesis and tumor progression.

The lab: Our laboratory studies the molecular mechanisms that safeguard the integrity of our genome. Specifically, we are interested in understanding how viral infection as well as chromatin structures influence DNA repair in mammalian cells. Recently, we discovered signaling and repair proteins that directly bind specific marks on the chromatin that surround DNA double-strand breaks (Panier et al. Mol Cell, Fradet-Turcotte et al. Nature 2013, Jacquet et al. Mol Cell 2016, Wilson et al. Nature 2016). To follow on these studies, the successful applicant will work with in vitro and cellular model systems to understand the impact of different chromatin structures on DNA repair processes. Throughout his/her studies, the applicant will develop a strong expertise on the biology of chromatin as well as on the processes that regulate genomic integrity. Additionally, he/she will acquire technical skills in biochemistry (protein purification, enzymatic assays, etc.) and molecular/cell biology (isolation of chromatin, confocal microscopy, cell culture, etc.). See for more information about the Fradet-Turcotte lab.

Skills needed

Summary of desirable qualifications: We are looking for a student who recently obtained a B.Sc (or the equivalent) in one of the molecular life sciences (e.g. genetics, biochemistry, molecular biology, etc.) and who are dynamic, hardworking as well as dedicated to scientific research.


Candidates with good grades and previous training in protein purification, molecular biology and/or cellular biology will be favored.

To apply, please send a cover letter, a CV with references (including grades) to

Amélie Fradet-Turcotte, Ph.D.
Department of Molecular Biology, Medical Biochemistry and Pathology
CHU de Québec Research Center – Université Laval
Cancer Research Center
Tel. (418) 525-4444 poste:16473

We thank all applicants for their interest; however, only those individuals selected for an interview will be contacted.
Offer number
Publishing date
06/02/2017 15:38
31/05/2017 17:00
Type of job
Étudiant maîtrise
L'Hôtel-Dieu de Québec
Main researcher
Amélie Fradet-Turcotte
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