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Research Center


Graduate Student Positions in Fundamental Oncology

Research project

The human genome contains more than 200 copies of the Ribosomal RNA (rRNA) genes. The activity of these genes determines tissue growth and is tightly linked to growth factor signalling, cell transformation and the actions of both oncogenes and tumour suppressors. However, in differentiated cells more than half of the rRNA genes are transcriptionally silenced by epigenetic modifications. The rRNA genes are important chromosome breakpoints implicated in genetic disorders such as Down’s Syndrome and Uniparental Disomy and are tightly linked to a range of cancers. Thus, rRNA gene silencing is important both for chromosomal stability and the prevention of cancer. In our laboratory we are investigating the molecular mechanisms that establish and maintain silencing of the rRNA genes, exactly how these mechanisms play a role in genome stability and how their loss is a factor in the establishment of pluripotency and the induction of cancer stem cells.

We are actively investigating the relationships between rRNA gene silencing, stem cell pluripotency and the induction of the pluripotent state in iPSCs. We are further studying the correlation between loss of rRNA gene silencing and human cancers. The studies involve the in vitro induction of cellular pluripotency and differentiation and its study using genome-wide expression and mapping techniques (ChIP-Seq, RNA-Seq, TT-Seq, Gro-Seq), Bioinformatics analysis and data-mining, and the de novo analyses of patient tissues. This work has recently been recognized by a 5 year grant from the CIHR.

Job description

We are seeking several new graduate students to become involved in these studies.

Skills needed

We are seeking several new graduate students to become involved in these studies. The criteria of selection are:
• Excellent undergraduate performance in Biochemistry, Biology, Microbiology, etc,
• Experience in basic aspects of molecular and cell biology,
• Enthusiasm and dedication to experimental science and advancement of knowledge.


Those interested should send a curriculum vitae and a photocopy of their university grades to:-
Tom Moss, PhD
Professor, Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, and Senior Investigator, St-Patrick Research Group in Basic Oncology, Oncology Division, CHU de Québec Research Centre.
Laboratory of Growth and Development
Pavillon St Patrick, 9 rue McMahon,
Quebec, PQ, G1R 3S3, CANADA.

Telephone:- 418 691 5281 or 418 525 4444 ext.15549/16945
Offer number
Publishing date
05/07/2017 10:26
01/09/2017 17:00
Type of job
Étudiant maîtrise
L'Hôtel-Dieu de Québec
Main researcher
Thomas Moss
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