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Research Center

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Steve Lacroix
Deputy director
Lisa Topolnik
2705, boulevard Laurier, RC-9800
Québec (Québec)
+1 418-654-2152
+1 418-654-2753

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The neuroscience group is organized into multidisciplinary teams that study the biological mechanisms underpinning the normal and pathological functioning of the central and peripheral nervous system and the muscular system. Researchers in this field seek to advance our understanding of physiopathology and develop new treatments for deficiencies and disabilities caused by lesions or neurological, psychiatric, and neuromuscular diseases. Research themes concern neurodegenerative, neuromuscular, and neurogenetic diseases, cerebral and spinal lesions and trauma, the regeneration and reorganization of the nervous system, mental health, ophthalmology, the development of biotherapy and standardized clinical evaluation methods, and neuromodulation treatments. Researchers are very active in Université Laval’s Regroupement Neurosciences et Santé mentale (Neurosciences and Mental Health Group).

Recent publications (see all publications in this area)

Lowery RL, Tremblay ME, Hopkins BE, Majewska AK. The microglial fractalkine receptor is not required for activity-dependent plasticity in the mouse visual system. Glia,  2017. Epub
Lessard AJ, LeBel M, Egarnes B, Prefontaine P, Theriault P, Droit A, Brunet A, Rivest S, Gosselin J. Triggering of NOD2 Receptor Converts Inflammatory Ly6Chigh into Ly6Clow Monocytes with Patrolling Properties. Cell reports,  2017. 20: 1830-1843
Jauvin D, Chretien J, Pandey SK, Martineau L, Revillod L, Bassez G, Lachon A, MacLeod AR, Gourdon G, Wheeler TM, Thornton CA, Bennett CF, Puymirat J. Targeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 Mice. Molecular therapy. Nucleic acids,  2017. 7: 465-474
Miville-Godbout E, Bourque M, Morissette M, Al-Sweidi S, Smith T, Jayasinghe D, Ritchie S, Di Paolo T. Plasmalogen precursor mitigates striatal dopamine loss in MPTP mice. Brain research,  2017. Epub
Levesque C, Hernandez G, Mahmoudi S, Calon F, Gasparini F, Gomez-Mancilla B, Blanchet PJ, Levesque D. Deficient striatal adaptation in aminergic and glutamatergic neurotransmission is associated with tardive dyskinesia in non-human primates exposed to antipsychotic drugs. Neuroscience,  2017. Epub
Mavrakanas TA, Fournier MA, Clairoux S, Amiel JA, Tremblay ME, Vinh DC, Coursol C, Thirion DJG, Cantarovich M. Neutropenia in kidney and liver transplant recipients: Risk factors and outcomes. Clinical transplantation,  2017. Epub
Hicks KE, Zhao Y, Fallah N, Rivers C, Noonan V, Plashkes T, Wai EK, Roffey DM, Tsai E, Paquet J, Attabib N, Marion T, Ahn H, Phan P, RHSCIR Network. A simplified clinical prediction rule for prognosticating independent walking after spinal cord injury: a prospective study from a Canadian multicenter spinal cord injury registry. The spine journal : official journal of the North American Spine Society,  2017. Epub
Paquet J, Rivers CS, Kurban D, Finkelstein J, Tee JW, Noonan VK, Kwon BK, Hurlbert RJ, Christie S, Tsai EC, Ahn H, Drew B, Bailey CS, Fourney DR, Attabib N, Johnson MG, Fehlings MG, Parent S, Dvorak MF, RHSCIR Network. The impact of spine stability on cervical spinal cord injury with respect to demographics, management, and outcome: a prospective cohort from a national spinal cord injury registry. The spine journal : official journal of the North American Spine Society,  2017. Epub
Bowerman M, Salsac C, Bernard V, Soulard C, Dionne A, Coque E, Benlefki S, Hince P, Dion PA, Butler-Browne G, Camu W, Bouchard JP, Delpire E, Rouleau GA, Raoul C, Scamps F. KCC3 loss-of-function contributes to Andermann syndrome by inducing activity-dependent neuromuscular junction defects. Neurobiology of disease,  2017. Epub
Gratuze M, Planel E. Regulation of brain insulin signaling: A new function for tau. The Journal of experimental medicine,  2017. 214: 2171-2173
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