Functional Analysis of Animal Behavior Service

of the CHU de Québec Research Center

[Version française]

Mission

The service is a state-of-the art facility designed to serve as a time-efficient and cost-effective service for researchers and pharmaceutical industry in need of behavioral and neuropharmacological analyses in small rodents. This service is offered in collaboration with the Animal services.

We will provide expertise in all aspects related to the consultation:

Services

The service is equipped to accommodate a full battery of behavioral tests relevant to learning and memory, sensory abilities, motor function, nociception, and anxiety-related behaviors. We are specialized in genetic and pharmacological phenotyping in both mouse and rat. In addition, the core facility provides expertise in an array of experimental models of nervous system disorders such as Alzheimer’s, Parkinson's, amyotrophic lateral sclerosis, Charcot -Marie-Tooth disease, cerebellar ataxia , muscular dystrophy, neuropsychiatric disorders, cardiovascular and metabolic disorders, as well as neuropathic pain, peripheral nerve and spinal cord lesions.

The available tests include a standardized battery, based on a highly validated behavioral methodology.

Additional tests may be available upon request.

Sensorimotor tests show/hide tests

Affective tests show/hide tests

Cognitive tests show/hide tests

Working with us

Researchers who are interested in developing a project in collaboration with the service are encouraged to contact the scientist in charge to discuss project objectives and the appropriate procedure to achieve the behavioral assays that allow addressing specific scientific hypotheses.

All behavioral testing procedures are made in accordance with the guidelines of the Canadian Council for Animal Care (CCAC). Each project within the service must be approved by the ethics committee for animal experiments at the research center du CHU de Québec.

Users must mention in their publications, the use of our services in the acknowledgments. The names of each member of the service, who makes a substantial contribution to the proposed project, must be listed as co-author in scientific publications.

Hourly rate: 70$/Hour

Contact information

Functional Analysis of Animal Behavior Service
CHU de Québec Research Center (CHUL)
2705 boulevard Laurier
Québec (Qc), G1V 4G2
Tel. (418) 525-4444, ext 46452

News

Publications

2015

Julia Hernandez-Rapp; Pascal Y Smith; Mohammed Filali; Claudia Goupil; Emmanuel Planel; Stephen T Magill; Richard H Goodman; Sebastien S. Hebert. Memory formation and retention are affected in adult miR-132/212 knockout mice. Accepted in Behavioural Brain Research

Filali M, Lalonde R, Gérard C, Coulombe Z, Tremblay JP. Sensorimotor skills in Fxn KO/Mck mutants deficient for frataxin in muscle. Brain Res. 2015 Mar 9. pii: S0006-8993(15)00182-1.

Audoy-Rémus J, Bozoyan L, Dumas A, Filali M, Lecours C, Lacroix S, Rivest S, Tremblay ME, Vallières L. GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease. Brain Behav Immun. 2015 Jan 28. pii: S0889-1591(15)00013-6.

2014

Catherine Gérard, Xiao Xiao, Mohammed Filali, Zoé Coulombe, Marie Arsenault, Jacques Couet, Juan Li, Marie-Claude Drolet, Pierre Chapdelaine, Amina Chikh, Jacques P Tremblay. An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models. Molecular Therapy—Methods & Clinical Development, 2014; 1, 14044.

2013

De Giorgio MR, Yoshioka M, Riedl I, Moreault O, Cherizol RG, Shah AA, Blin N, Richard D, St-Amand J. Trefoil factor family member 2 (Tff2) KO mice are protected from high-fat diet-induced obesity. Obesity. 2013 Jul;21(7):1389-95.

Pimentel-Coelho PM, Michaud JP, Rivest S. Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice. Neurobiol Aging. 2013 Mar;34(3):679-93.

Michaud JP, Hallé M, Lampron A, Thériault P, Préfontaine P, Filali M, Tribout-Jover P, Lanteigne AM, Jodoin R, Cluff C, Brichard V, Palmantier R, Pilorget A, Larocque D, Rivest S. Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1941-6.

2012

Naert G, Rivest S. Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice. Front Cell Neurosci. 2012 Nov 1;6:51.

Filali M, Lalonde R, Theriault P, Julien C, Calon F, Planel E. Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD). Behav Brain Res. 2012 Oct 1;234(2):334-42.

Michaud JP, Richard KL, Rivest S. Hematopoietic MyD88-adaptor protein acts as a natural defense mechanism for cognitive deficits in Alzheimer's disease. Stem Cell Rev. 2012 Sep;8(3):898-904.

Drouin-Ouellet J, LeBel M, Filali M, Cicchetti F. MyD88 deficiency results in both cognitive and motor impairments in mice. Brain Behav Immun. 2012 Aug;26(6):880-5.

Naert G, Rivest S. Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. Mol Med. 2012 Mar 30;18:297-313.

2011

Filali M, Lalonde R, Rivest S. Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis. Behav Brain Res. 2011 Nov 20;225(1):215-21.

Filali M, Lalonde R, Rivest S. Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease. Physiol Behav. 2011 Oct 24;104(5):880-5.

Nadeau S, Filali M, Zhang J, Kerr BJ, Rivest S, Soulet D, Iwakura Y, de Rivero Vaccari JP, Keane RW, Lacroix S. Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain. J Neurosci. 2011 Aug 31;31(35):12533-42.

Filali M, Dequen F, Lalonde R, Julien JP. Sensorimotor and cognitive function of a NEFL(P22S) mutant model of Charcot-Marie-Tooth disease type 2E. Behav Brain Res. 2011 Jun 1;219(2):175-80.

Filali M, Lalonde R, Rivest S. Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology. 2011 May;60(6):930-6.

Naert G, Rivest S. CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2011 Apr 20;31(16):6208-20.

Michaud JP, Richard KL, Rivest S. MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease. Mol Neurodegener. 2011 Jan 14;6(1):5.

2010

Dequen F, Filali M, Larivière RC, Perrot R, Hisanaga S, Julien JP. Reversal of neuropathy phenotypes in conditional mouse model of Charcot-Marie-Tooth disease type 2E. Hum Mol Genet. 2010 Jul 1;19(13):2616-29.

2009

Boissonneault V, Rivest S. [The hematopoietic cytokine M-CSF as a cure for Alzheimer's disease]. Med Sci (Paris). 2009 Aug-Sep;25(8-9):666-8.

Boissonneault V, Filali M, Lessard M, Relton J, Wong G, Rivest S. Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain. 2009 Apr;132(Pt 4):1078-92.

Filali M, Lalonde R, Rivest S. Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease. Genes Brain Behav. 2009 Mar;8(2):143-8.

2008

Barrette B, Hébert MA, Filali M, Lafortune K, Vallières N, Gowing G, Julien JP, Lacroix S. Requirement of myeloid cells for axon regeneration. J Neurosci. 2008 Sep 17;28(38):9363-76.

Richard KL, Filali M, Préfontaine P, Rivest S. Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci. 2008 May 28;28(22):5784-93.

2007

Kang J, Rivest S. MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis. J Cell Biol. 2007 Dec 17;179(6):1219-30.

Boivin A, Pineau I, Barrette B, Filali M, Vallières N, Rivest S, Lacroix S. Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. J Neurosci. 2007 Nov 14;27(46):12565-76.