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René C-Gaudreault

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Hôpital Saint-François-d'Assise
10, rue de l'Espinay
Québec (Québec)

+1 418-525-4444, poste 52363
+1 418-525-4372

Projet(s) de recherche reconnu(s) par l'Université Laval

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Publications récentes (voir toutes les publications de ce chercheur)

Lefebvre CA, Forcellini E, Boutin S, Cote MF, C-Gaudreault R, Mathieu P, Lague P, Paquin JF. Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity. Bioorganic & medicinal chemistry letters,  2017. 27: 299-302
Fortin S, Charest-Morin X, Turcotte V, Lauvaux C, Lacroix J, Cote MF, Gobeil S, C-Gaudreault R. Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells. Journal of medicinal chemistry,  2017. 60: 4963-4982
Fortin JS, Benoit-Biancamano MO, C-Gaudreault R. Discovery of ethyl urea derivatives as inhibitors of islet amyloid polypeptide fibrillization and cytotoxicity. Canadian journal of physiology and pharmacology,  2016. 94: 341-6
Vesper AR, Lacroix J, C-Gaudreault R, Tajmir-Rihai HA, Berube G. Synthesis of novel C2-symmetric testosterone dimers and evaluation of antiproliferative activity on androgen-dependent and -independent prostate cancer cell lines. Steroids,  2016. 115: 98-104
Bouchoucha M, Côté MF, C-Gaudreault R, Fortin MA, Kleitz F. Size-Controlled Functionalized Mesoporous Silica Nanoparticles for Tunable Drug Release and Enhanced Anti-Tumoral Activity Chemistry of materials : a publication of the American Chemical Society,  2016. 28: 4243-4258
Gagne-Boulet M, Fortin S, Lacroix J, Lefebvre CA, Cote MF, C-Gaudreault R. Styryl-N-phenyl-N'-(2-chloroethyl)ureas and styrylphenylimidazolidin-2-ones as new potent microtubule-disrupting agents using combretastatin A-4 as model. European journal of medicinal chemistry,  2015. 100: 34-43
Bouchoucha M, C-Gaudreault R, Fortin MA, Kleitz F. Mesoporous Silica Nanoparticles: Selective Surface Functionalization for Optimal Relaxometric and Drug Loading Performances Advanced functional materials,  2014. 24: 5911–5923
Fortin JS, Côté MF, Deschesnes RG, Patenaude A, Lacroix J, Benoit-Biancamano MO, C.-Gaudreault R. Microtubule disrupting N-phenyl-N’-(2-chloroethyl)ureas display anticancer activity on cell adhesion, p-glycoprotein and BCL-2-mediated drug resistance. International journal of pharmacy and pharmaceutical sciences,  2014. 6: 171-179
Fortin S, Wei Lianhu, Kotra LP, C-Gaudreault R. Novel Cytocidal Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl) Benzenesulfonates and Benzenesulfonamides with Affinity to the Colchicine-Binding Site: Is the Phenyl 2-Imidazolidinone Moiety a New Haptophore for the Design of New Antimitotics? Open journal of medicinal chemistry,  2014. 5: 9-22
Marceau F, Bouthillier J, Houle Steeve, Sabourin T, Fortin JP, Morissette G, Lodge R, Fortin S, C-Gaudreault R, Bawolak MT, Koumbadinga MT, Gérémy A, Roy C, Charest-Morin X, Gera L. Bradykinin receptors: agonists, antagonists, expression, signaling and adaptation to sustained stimulation Journal of Angioedema,  2013. 1: 9-17
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